高选择性迷走神经切断加胃窦粘膜切除术后胃窦运动功能的研究

The changes of glycine content in brainhomogenates after acute craniocerebral injuryand the effects of glycine on NMDA receptorbinding of brain synaptic plasma membrane incats

高选择性迷走神经切断术（ＨＳＶ）加胃窦粘膜切除术（ＭＡ）同时去除了脑相和胃相的胃酸分泌，理论上是合理的。本实验结果提示：尽管横断了胃体，损毁了胃窦粘膜下神经丛，术后胃窦肌电活动频率有所减慢，但保留带有神经支配的浆肌层可发挥正常的生理功能，胃排空不受影响，无十二指肠返流过量，这为临床上进一步应用该术式提供了一定理论依据。

The glycine contents were measured inbilateral cerebral cortex at 5mins,2h,4h, 6hafter craniocerebral injury as compared to ham operation control group(n=5),and thechanges of(3H)-CPP specific binding to NM-DA receptor evaluated in l0-4 M,10-3 Mglycine solutions or glycine-free solutions(GFS).The significant elevation of glycinecontent was found in the lesioned cerebral cor-tex at 5mins postinjury, which was related tobrain injury。 The Ro of(3H)-CPP binding toNMDA receptor decreased significantly in10-3 M glycine solutions as compared to that inGFS.The results suggest that glycine,by in-creasing affinity of excitatory amino acidsbinding to NMDA receptors,may contributeto secondary brain injury in pathophysiology。