大肠癌患者门静脉及外周血癌胚抗原与组织病理变化的关系

Correlation between carcinoembryonicantigen levels of portal and peripheral bloodand histopathologic variables

为了研究门静脉及外周血癌胚抗原（ＣＥＡ）与组织病理变化的关系，我们检测了６２例大肠癌患者门脉及外周血的ＣＥＡ。结果显示，门静脉血ＣＥＡ显著高于外周血；门脉及外周血ＣＥＡ的升高与静脉侵犯及Ｄｕｋｅｓ分级有强相关关系，门脉血ＣＥＡ的升高还与肿瘤大小、分化程度、淋巴结转移有关。ＣＥＡ值随静脉侵犯程度的增加而升高。手术刺激有静脉侵犯的癌肿后，ＣＥＡ显著升高，没有静脉侵犯者则无变化。结果表明，ＣＥＡ主要是通过门静脉进入外周血。ＣＥＡ的升高表明癌肿的静脉侵犯业已发生，预后不良。

To research into the corralation betweenearcinoembryonic antigen(CEA)levels of pe-ripheral and portal blood and histopathologicvariables,62 patients with colorectal cancerwere examined.Theresult showed that CEALevels of portal blood were significantly higherthan those of peripheral blood.Elevation ofCEA levels in portal and peripheral blood wasmost highly correlated with the venous inva-sion and Dukes’dassification. CEA levels inportal blood were also related to tumor size,tumor differentiation,node metastasis.Neva-tion of CEA levels was following the grade ofvenous invasion.CEA levels was following thegrade of venous invasion. CEA levels rose fol-lowing operative stimuli to cancer lesions withvenous invasion.However,the levels did notrise in the lesions without the invasion.Theseresults sugggest that CEA may be hematoge-nously drained by the portal system via thedrainging vein from the cancer lesions.The pa-tients with high CEA levels have a poor prog-nosis because venous invasion has already oc-curred.