猪繁殖与呼吸综合征疫苗研究进展

Progress in Vaccines Against Porcine reproductive and respiratory syndrome

猪繁殖与呼吸综合征是一种引起母猪繁殖障碍和新生仔猪呼吸道症状及高死亡率的传染病。已几乎遍极世界所有养猪国家,在中国的流行和分布也日益广泛,危害日益严重。此病的传播给世界养猪业造成严重经济损失,受到国内外学者的高度重视,对此病的研究也正在逐渐深入,特别是免疫学及其疫苗的研究正日益受到关注。文章就猪繁殖与呼吸综合征病毒的灭活疫苗、弱毒疫苗和基因工程疫苗的研究进展和使用现状做了系统地阐述,特别是通过合理地选择和使用免疫佐剂,如γ干扰素、霍乱毒素及可溶性β葡聚糖等来改进疫苗作用方面进行了阐述。

Porcine reproductive and respiratory syndrome (PRRS) is a highly infectious viral disease of swine. It causes respiratory problems and high mortality in neonatal piglets and reproductive failure in enceinte sows.PRRS has nearly transmitted to all parts of the world. It causes significant economic loses to the pork industry in many countries all over the world. Many advances have been achieved in the causative agent of PRRS, PRRS virus (PRRS), especially in virus immunology and vaccine development.Progress on PRRSV vaccines, including killed vaccines, modified live vaccines and genetic engineering vaccines, were reviewed in this paper. Strategies using immunological adjuvants, such as IFN-γ, cholera toxin (CT), soluble β-glycan, and so on, were also discussed.