摘要
金丝桃素为贯叶连翘中抗病毒的活性单体,属二蒽酮类。植物化学和药理学研究发现,金丝桃素具有抗抑郁、抗肿瘤、抗病毒、止血消炎以及光动活性等特点。目前关于金丝桃素的研究,国内多处于药理临床研究阶段,主要集中于肿瘤的辅助治疗和抗病毒研究方面,国外现已将其用于抑郁症、艾滋病等的临床治疗。鉴于金丝桃素突出的抗病毒作用,以及作为癌症的光化学治疗的一种有前途的内源性光敏剂,文章对金丝桃素的分离提取及其多种药理作用做了系统阐述,以期为金丝桃素的基础研究和临床应用提供借鉴和参考。
Hypericum perforatum L. is a traditional medicinal plant mainly for the treatment of depression, it has also been used as a medical plant for its anti-inflammatory, sedative and analgesic. Hypericin (HY) is an active constituent with the highest bioactivity extracted from it and belong to naphthodianthrones compound.The researcha show that Hy is potential as an anticancer drug and antivirus drug, it can inhibit some retroviral virus and has photosensitive. Now, the studies for HY in china in the stage of clinical pharmacology test, but of clinical treatment for depression and AIDS overseas. This review summarizes the role of HY in its extraction and the pharmacological effects, in order to bring reference for basic research and applications in clinical.
出处
《动物医学进展》
CSCD
2005年第5期32-35,共4页
Progress In Veterinary Medicine
关键词
金丝桃素
贯叶连翘
提取
药理作用
抗病毒
hypericin
extract
antivirus
anticancer
anti-depression
photosensitive
