期刊文献+

乳腺癌和瘦素相关性研究进展 被引量:3

下载PDF
导出
摘要 肥胖是乳腺癌的一个危险因素,瘦素作为肥胖基因的产物,与肥胖密切相关。在乳腺癌患者中,血清中瘦素水平显著升高;乳腺癌患者的脂肪组织和乳腺上皮细胞中也发现有Lpm RNA和瘦素受体表达。研究还证实:瘦素可以通过旁分泌和内分泌作用于乳腺上皮细胞,促使乳腺癌细胞的生长。结果表明,瘦素作为肥胖因子可能在肥胖致乳腺癌的过程中起重要作用。提供了一个为什么肥胖症与乳腺癌相关的解释。
出处 《国外医学(外科学分册)》 2005年第3期208-210,共3页 Foreign Medical Sciences(section of Surgery)
  • 相关文献

参考文献17

  • 1Catalano S, Marsico S, Giordano C, et al. Leptin enhances, via AP-1, expression of aromatase in the MCF-7 cell line. J Biol Chem,2003, 278(31 ) : 28668-28676.
  • 2Hu X, Juneja SC, Maihle NJ, et al. Leptin - a growth factor in normal and malignant breast cells and for normal mammary gland development. J Natl Cancer Inst, 2002, 94(22) : 1704-1711.
  • 3Stephenson GD, Rose DP. Breast cancer and obesity: an update.Nutr Cancer, 2003, 45(1): 1-16.
  • 4O'Neil JS, Burow ME, Green AE, et al. Effects of estrogen on leptin gene promoter activation in MCF-7 breast cancer and JEG-3 choriocarcinoma cells:selective regulation via estrogen receptors alpha and beta. Mol Cell Endocrinol, 2001, 176(1-2): 67-75.
  • 5Ozet A, Arpaci F, Yilmaz MI, et al. Effects of tamoxifen on the serum leptin level in patients with breast cancer. Jpn J Clin Oncol,2001, 31 (9) : 424-427.
  • 6董庆玉,高菊兴,张纪云,孙宝义,王振英,韩建奎.血清胰岛素样生长因子-1、瘦素以及性激素与女性乳腺癌的相关性研究[J].放射免疫学杂志,2003,16(6):360-362. 被引量:2
  • 7Tessitore L, Vizio B, Jenkins O, et al. Leptin expression in colorectal and breast cancer patients. Int J Mol Med, 2000, 5(4):421-426.
  • 8Petridou E, Papadiamantis Y, Markopoulos C, et al. Leptin and insulin growth factor I in relation to breast cancer. Cancer Causes Control, 2000, 11(5): 383-388.
  • 9Stattin P, Soderberg S, Biessy C, et al. Plasma leptin and breast cancer risk: a prospective study in northern Sweden. Breast Cancer Res Treat, 2004, 86(3): 191-196.
  • 10Laud K, Gourdou I, Pessemesse L, et al. Identification of leptin receptors in humor breast cancer: functional activity in the T47-D breast cancer cell line. Mol Cell Edocrinol, 2002, 188 ( 1 - 2 ) :219.

二级参考文献1

共引文献1

同被引文献37

引证文献3

二级引证文献8

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部