自体静脉移植血管的顺应性特点和显微结构成份定量分析

Evolution of biomecbanical changes and microstruc-tural components in autogenous vein grafts

自体静脉是中小动脉重建的首选材料，但仍有一定的近、远期栓塞率。本研究评价了自体静脉移植血管顺应性特点，并采用图像分析技术测定了自体静脉移植后的血管管壁弹力纤维和胶原纤维的相对含量。结果发现，自体静脉移植术后移植血管与宿主动脉间顺应性差异始终存在，但顺应性差异与血流频谱形态间无确定的关系。这种顺应性差异体现在自体静脉移植血管具有与正常静脉相同的顺应性特点，不同于正常动脉。以管壁胶原纤维和弹力纤维含量比值表示血管的刚度，结果显示移植血管刚度值与正常静脉相同，低于正常动脉。结构成份的测定结果进一步支持功能评价的结果。

AbstractWe evaluated the compliance characteristics of au-togenous vein grafts clinically andexperimentally. Theimage analysis instrument was applied in measuring therelative contents of elastin and collagen of the grafts.The resuIts showed the consistent compliance mis-match between the vein graft and the host artery, butno definitive bearing on abnormal blood flow velocitywaveform by the compliance mismatch. The compli-ance characteristics of the vein graft resembled these ofthe vein rather than those of the artery. The relativecontents of elastin and collagen within the graft walland the ratio of collagen to elastin( C/E)did notchange significantly as a function of time. The veingraft and vein had the similar value of C/E, which waslower than that of the artery.