化湿利水泄浊合剂对高血压病患者血管内皮依赖性舒张功能的影响

Effect of “Huashi Lishui Xiezhuo Mixture” on Endothelium-Dependent Vasodilatation in Essential Hypertension Patients

为探讨化湿利水泄浊合剂对高血压病(EH)患者血管内皮依赖性舒张功能(FMD)保护作用的机制,将50例高血压病患者随机分为治疗组(25例)和对照组(25例),分别采用化湿利水泄浊合剂和西拉普利治疗,治疗前后分别用高分辨率超声检测各组患者的肱动脉内皮依赖性舒张功能,同时用硝酸还原法测定血清一氧化氮(NO)含量。结果:高血压病患者存在FMD失调,用化湿利水泄浊合剂治疗后患者的FMD明显改善;NO水平升高(P<0. 05)。结论:化湿利水泄浊合剂对EH患者血管内皮依赖性舒张功能有改善作用。

To investigate the mechanism of “Huashi Lishui Xiezhuo Mixture” in the protection of endothelium dependent vasodilatation in the patients with essential hypertension, 50 subjects were equally divided into treatment group and control group, and then respectively treated by this Mixture and Ciazapril; endothelium dependent vasodilatation and the contents of NO were detected before and after treatment in both groups. Results: There was endothelium dependent vasodilatation disorder in essential hypertension patients; this Mixture could obviously improve endothelium dependent vasodilatation and increase the contents of NO ( P <0.05). Conclusion: “Huashi Lishui Xiezhuo Mixture” can improve the endothelium dependent vasodilatation of essential hypertension.