甲状旁腺机能亢进症患者骨小梁结构的改变（骨形态计量学研究）

The morphological changes in trabecular architectureof bone iu severe primary hyperparathyroidism

作者用骨形态计量学的方法分析了１０例经手术证实的原发性甲状旁腺机能亢进患者的髂骨活检标本。结果表明，患者的平均骨小梁宽度增加，平均类骨质宽度增加，骨小梁骨体积增加。骨小梁类骨质和吸收表面都增加，而骨小梁静止表面减少。动力学参数的结果表明，骨小梁表面单标记和双标记的比例较对照组明显增加。患者的矿化沉积速率增加，矿化延迟时间延长。上述结果表明，原发性甲状旁腺机能亢进患者的小梁骨体积得到了保留，骨再建活动活跃。类骨质的增宽和矿化时间的延长，则表明这些患者合并程度不同的软骨病，这也可能是我国部分患者无典型的高钙血症的原因。

AbstractBy histomorphometry bone biopsy specimens wereevaluated from 10 patients with severe primary hyper-parathyroidism(PHPT).The data suggest that themean trabecular width and trabecular bone volumewere slightly,but not significantly increased. As in-dices of bone remodeling activity,both trabecular os-teoid surface and trabecular resorption surface weresignificantly increased indeed, indicating high boneturn-over occurred in PHPT. The dynamic studyshowed that much more trabeculat bone surface wascovered either with single or double tetracycline labelsin PHPT than in control. The overproduction of os-teoid in the patients leads to the accumulation of os-teoid on the trabecular surface;Moreover,the meanosteoid width seemed to be thecker in PHPT than incontrol,suggesting the Co-existance of osteomalacia,which migh be a possible explanation for eucalcemiausually seen in the majority. Part of chinese PHPT pa-tients.