人免疫缺陷病毒的垂直传播感染及其在婴儿体内的复制

VERTICAL TRANSMISSION OF HIV AND REPLICATION IN VIVO

人免疫缺陷病毒（ＨＩＶ）感染的垂直传播机制和途径仍然是有争议的课题。我们研究了５０例血清阳性妇女和她们的婴儿。早在婴儿出生后的两个月内，我们就能对有无ＨＩＶ感染作出诊断。诊断结果阳性或阴性在婴儿６～９个月时复查没有改变。３０％左右的血清阳性妇女其ＨＩＶ传播给婴儿。我们的结果支持ＨＩＶ的传播发生于妊娠晚期或围产期。寻找ＨＩＶ－ＲＮＡ的回顾性研究证实在出生后几周内婴儿体内有ＨＩＶ的复制。

The mechanisms and route of transmission of HIVinfection from a mother to her child is still the subject ofsubstantial debate.wehave conductedaprospective longitudjnal study of 50 infants born to seropositive mothers in two hospitalsin Paris .We have diagnosed HIV infection in 16 infants before the end of their second month,no changes were ob-served at 6-9 months.Our study provided the prospectively acquired data on HIV status during the first weeks of life.Approximate-ly 30%of HIV infected pregnant women transmited infection to their fetus.Our results favour the hypothesis thattransmission of HIV-1 might take place either at the end of pregnancy or at delivery.The results of our retrospective search for HIV-1genomic RNA confirm that active replication of HIV takesplace during the first weeks of life.