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几种中药提取成分对人PMN吞噬杀菌功能的影响 被引量:6

THE EFFECTS OF SEVERAL EXTRACTIVES OF TRADITIONAL CHINESE PHARMACEUTICALS ON HUMAN POL YMORPHONUCLEAR LEUKOCUTES PHAGOCYTIC AND KILLING FUNCTION
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摘要 用人参茎叶皂甙、黄芪多糖、云芝胞内多糖、猪苓多糖及阿魏酸钠预先处理分离的人PMN,测定PMN吞噬杀伤金黄色葡萄球菌时的CL值(30分种积分值和峰值,CL30及Peak)和MPO水平。结果表明,人参茎叶皂甙、黄芪多糖、云芝胞内多糖和猪苓多糖在一定浓度范围内对人PMN的CL和MPO水平均有明显增强作用(P<0.01),而阿魏酸钠则抑制PMN的CL和MPO水平(P<0.01)。这表明人参茎叶皂甙、云芝胞内多糖、猪苓多糖和黄芪多糖均能增强人PMN的吞噬杀菌能力,阿魏酸钠则抑制人PMN的吞噬杀菌能力。 While the respiratory burst occurs during the process of phagocytosis and bacteria-killing of polymorphonu-cleus leucocytes(PMN),the chemiluminescence(CL )appears.The luminol enhanced CL response is related withthe release of myeloperoxidase (MPO ).The separated PMN were pretreated separately with ginsenoside,astra-galu-polysaccharide (APS ),krestin polysaccharide(KPS ),polyporus umbellatus or sodium ferulate, then we ob-served PMN-CL response(CL30 and peak )and MPO upon the stimulation with S. aureus. Enhancement of both CLand MPO occured when the PMN were pretreated with ginsenoside,APS ,KPS ,polyporus umbellatus (P <0.01 ).Inhibition of both CL and MPO occured when the PMN were pretreated with sodium ferulate(P<0.01 ). Thesefindings indicated that ginsenoside,APS,KPS,polyporus umbellatus enhanced the phagocytosis and bacteria-killingfunction of human PMN, but sodium ferulate reduced the human PMN function.Either enhancement or reductionwas associated wih the MPO level of human PMN.
出处 《中华微生物学和免疫学杂志》 CAS CSCD 北大核心 1994年第4期277-279,共3页 Chinese Journal of Microbiology and Immunology
基金 中国科学院自然科学基金
关键词 中药 提取成分 多形核白细胞 CL Polymorphonucleus leucocytes leucocytes(PMN) Chemilumino-escence(CL) Myeloperoxidase(MPO) Several extractives of traditional chinese medicines
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参考文献5

  • 1张力平,中华微生物和免疫学杂志,1994年,14卷,2期,121页
  • 2彭宜红,首都医学院学报,1993年,14卷,4期,341页
  • 3张力平,中国免疫学杂志,1987年,3卷,6期,328页
  • 4杨虎天,老年学杂志,1985年,3卷,1期,17页
  • 5黄乔书,药学学报,1982年,3卷,200页

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