大鼠器官中MRI增强试剂弛豫度的测量

Measurements of the Relaxivity of Contrast Agent in Rat Tissues

测量了钆螯合物的磁共振成像(MRI)对比度增强试剂钆双胺(omniscan)在大鼠不同组织,包括肝、脾、肾、心脏、肌肉和血液中的核磁共振(NMR)弛豫度,以及在不同的大分子介质环境,如小牛血清白蛋白(BSA)和甲基纤维素(MC)溶液中的弛豫度。实验数据表明:增强试剂钆双胺在小鼠的不同组织中的弛豫度互不相同,在大分子介质溶液中弛豫度随介质大分子浓度的增大而提高。

With a paramagnetic gadodiamide contrast agent,NMR relaxivity was measured in rat tissues such as liver,spleen,kidney,heartand blood,as well as in various media of macromolecules such as methyl celluˉlose and albumin.The results of this study demonstrate that the relaxivity varies between different tissues and increases with the concentration of macromolecules.