当归对正常及肝硬化犬门脉血液动力学的影响

EFFECTS OF RADIX ANGELICAE SINENSIS ON PORTALHEMODYNAMICS IN NORMAL AND CIRRHOTIC DOGS

研究当归对正常（ｎ＝６）和慢性胆管结扎肝硬化犬（ｎ＝８）的全身和门脉血液动力学的影响。结果表明，给正常及肝硬化犬静滴当归注射液（８０ｍｇ／ｋｇ／ｍｉｎ），可以明显降低正常犬ＭＡＰ（１９．４５：１７．３４ｋＰａ，Ｐ＜０．０２），对ＨＲ和ＩＶＣＰ没有影响，但肝硬化犬ＭＡＰ、ＨＲ和ＩＶＣＰ均没有明显变化。相反，应用当归注射液后肝硬化犬ＷＨＶＰ（２．４２±０．８０：１．７９±０．７６ｋＰａ，Ｐ＜００１）、ＨＶＰＧ（１．６９±０．７０：１．０６±０．６８ｋＰａ，Ｐ＜００１）、Ｐｐｖ（２．５０±０．７９：１．８１±０．７４ｋＰａ，Ｐ＜０．００１）和Ｒｐｖ（０．８９±０．４８：０．５８±０．４０ｋＰａ·Ｓ／Ｌ，Ｐ＜００１）显著下降，但Ｑｐｖ、ＱＨＡ和ＱＴＬ治疗前后基本保持稳定。研究证明，当归注射液是一种治疗门脉高压的安全有效药物。

ffects of Radix Angelicae Sinensis(RAS)on systemic and portal hemodynamics wereinvestigated in normal(n=6)and cirrhotic dogs(n=8),induced by bile duct ligation.Thepresent study showed that,after intravenous administration of RAS(80mg/kg/min),in thenormal MAP was significantly decreased(19.45vs.17. 34kPa,P< 0,02),HR and IVCP wereunchanged, but in the cirrhotics the were not affected.In contrast to, portal hemodynamicsin the normal did not change compared with the basal levels, whereas WHVP (2.42± 0.80 vs.1.79± 0.76kPa, P<0.001),HVPG(1.69± 0.70 vs,1.06± 0.68kPa,P<0.001).Ppv(2.50± 0.79 vs.1.81 ± 0.74kPa, P<0.001) and Rpv(0.89± 0.48 vs.0.58 ± 0.40kPa.s/L,P<0.01)in the cirrhoticswere remarkebly reduced,portal blood flow was not defferent to that before treatment.Theresults suggest that RAS is a safe,effective traditional Chinese medicine treating portalhypertension.