甲醛四氢叶酸钙和5－氟尿嘧啶联合应用治疗进展性胃肠道癌

COMBINATION OF 5-FLUOROURACIL AND FOLINIC ACID IN TREATMENT OF ADVANCED GASTROINTESTINAL CANCER

自１９８８年起对７２例进展性胃肠道癌肿患者进行了甲醛四氢叶酸钙（ＦＡ）和５－氟尿嘧啶（５一ＦＵ）联合化疗。在３４例治疗性联合化疗中，对可评价的３１例进展性结直肠癌（２１例）和胃癌（１０例）进行效应分析。肿瘤完全消退（ＣＲ）７例，部分缓解（ＰＲ）１２例，总有效率６１．２９％，药物效应时间２个月，效应持续时间１～１６个月（中位１１个月），有效者中位存活时间１２个月，一年存活率４７．３６％，最长存活２８个月。本组中１２例以往曾接受５一ＦＵ化疗无效，在改用本方案后获ＣＲ２例、ＰＲ４例，有效率为５０％。毒性反应主要表现在胃肠道和造血系统。

econd Medical University 72 patients with advanced gastrointestinal cancer had been treated with 5-fluorouracil(5-FU)combined with folinic acid since 1988.The effectiveness of combined therapy in 3l cancepatients were evaluated.7 of them had complete remission(CR)and l2 partial remission(PR)with an overall response rate of 61.29%and a median response duration of l l months (1-16months).The median survival rate was l2 months with one year su1rvival rate of 47.36%。 Thelongest one survived for more than 28 months.Among l2 patients who were resistant toprevious single 5-FU treatment, 2 patients showed CR and 4 showed PR to 5-FU and folinicacid combined therapy with a response rate of 50%.The toxicities were mainly of thegastrointestinal tract and hematopoitic system.