维甲酸对大鼠实验性腺胃粘膜癌前病变的逆转治疗作用

THERAPEUTICEFFECTSOFRETINOlCACIDONEXPERI- MENTALLYINDUCEDPRECANCEROUSLESIONSOFTHE GLANDULARGASTRICMUCOSAINWISTARRATS

本文旨在观察维甲酸对大鼠胃粘膜癌前病变的作用，结果示，维甲酸治疗组大鼠腺胃粘膜上皮化生、中重度异型增生和胃癌的发生率（７２．０％、２４．０％、０％）均显著地低于未加治疗的对照组（１００．０％、５２．０的、１６．０％）（Ｐ＜０．０１、Ｐ＜０．０５）；治疗组大鼠幽门腺和胃底腺平均肠化腺体数（１３０．２±９３．９、５１．５±３９．１）及硫酸粘液阳性肠化发生率（３６．０％）亦显著地低于未加治疗的对照组（４４２．４±２３０．０、２４７．４±１１２．０，８４．０％）（Ｐ＜０．０１），本实验中未观察到维甲酸明显的毒副作用，说明维甲酸对大鼠实验性腺胃粘膜癌前病变有良好的治疗作用；这为探讨人胃癌前病变的治疗提供了新途径。

he therapeutic effects of retinoic acid(RA)on experimentally induced precancerouslesions of the glandular gastric mucosa in Wistra rats were studied. Intestinal metaplasia(IM)anddysplasia in glandular stomach of rats were induced by giving both 003%ranitidinein diet and 50μg/ml N-m ethyl- N’-n itro- N-nitrosoguanidine(MNNG) in drinking water adlibitum for 20 weeks. From the beginning of the 36th week, RA(40mg/kg.body weight/day)was administered to rats of the treated group for 8 weeks and subsequently rats were killed。Results showed that the incidences of IM (72.0%), moderate and severe dysplasia (24.0%)andgastric cancer(0%)and the numbers of metaplastic glands in both the pyloric and fundicgland mucosa(130.2 ± 93.9, 51.5 ± 39.1) were significantly lower in RA treated group than inuntreated group(100.0%, 52.O%,16.0%,442.4± 230.0,247.4± 112.0 respectively) (P<0.0l andP<0.05).There was also significant difference(P<0.01) in the incidence of sulfomucinpositive IM between the RA treated group(36.0%)and untreated group (84.0%).Obvious sideeffects of RA were not observed.It is therefore concluded that RA is an effective therapeuticagent for the precancerous lesions of glandular gastric mucosa in Wistar rats。