摘要
本文采用人工虫草菌丝对大鼠白蛋白免疫损伤性肝纤维化进行治疗，并用有一定抗纤维化作用的秋水仙碱作为阳性对照。结果表明：人工虫草能减轻肝脏的炎性细胞浸润和肝细胞变性坏死；同时能抑制总胶原、Ⅰ、Ⅲ型胶原在肝内的沉积，并可使已形成的胶原重新溶解和吸收，其作用与秋水仙碱相仿，本文验证了人工冬虫夏草的抗纤维化作用并对可能的机理进行了探讨。
e investigate the effect of cordyceps mycelium preparation on the human
al-bumin-immuno-induced hepatic fibrosis of rats,using colchicine as control.The results
revealed that the depositions of total and types Ⅰ and Ⅲ collagen in the ratliver after
treatment with both cordyceps and colchicine were distinctly less than theuntreated group (P<0.
05),and there was no significant difference between the cordyceps andcolchicine groups.EM
showed that cordyceps could decrease the infiltration of inflammtorvcells and increase the
phagocytic function of Kupffer cells.Additionally it could decrease thedeposition of IgG-IC along
the sinusoids of fibrotic liver, These results would suggest thatcordyceps could inhibit the liver
coIlagen accumulation by scavenging the IgG-IC or bystimulating collagenase activity.
出处
《中华消化杂志》
CAS
CSCD
北大核心
1994年第6期333-335,共3页
Chinese Journal of Digestion
关键词
肝纤维化
肝硬化
清蛋白
免疫损伤
冬虫夏草
Treatment of liver fibrosis
Ⅰ、Ⅲ、type coIlagen
Cordyceps mycelium
Alb-umin
immune injury.
