常压氧疗法治疗胎儿心功能异常和胎盘功能下降的疗效分析

The effectiveness of maternal normobaric oxygen therapy on fetal cardiac dysfunction and placental circulation disorder

目的探讨常压氧疗法治疗胎儿心律失常、胎儿心脏瓣膜返流和胎盘循环功能下降的疗效。方法选择多普勒胎儿超声检查诊断为各类胎儿心律失常(331例)、胎儿心脏瓣膜返流(81例)和胎盘循环功能下降(88例)的孕妇共500例,作为常压氧治疗组。采用常压氧疗法进行治疗:孕妇在常压环境下戴面罩吸氧,供氧浓度为99.5%,氧流量为10L/min,吸氧时间为30min,中间休息5min,每日吸氧1次,10次为1个疗程。另设不进行常压氧治疗的194例胎儿心功能异常和胎盘功能下降的孕妇作为对照组。结果常压氧治疗组治愈率为:各类心律失常95.8%,瓣膜返流84.0%,胎盘循环功能下降95.5%;对照组治愈率为:各类心律失常37.5%,瓣膜返流34.1%,胎盘循环功能下降23.3%,2组比较差异均有统计学意义(P<0.01),常压氧治疗组疗效明显优于对照组。结论常压氧疗法治疗胎儿心律失常、心脏瓣膜返流和胎盘循环功能下降疗效肯定、安全、无创,值得临床推广。

Objective To explore the therapeutic effects of maternal normobaric oxygen therapy (MNO) on fetal arrhythmia (FA), fetal cardiac valve reflux (FCVR) and disorder of placental circulation (DPC). Methods Five hundred pregnant women diagnosed by fetal Doppler echocardiography as being with FA (331 cases), FCVA (81 cases) and DPC (88 cases), were treated with MNO (a MNO group), while 194 pregnant women with fetal cardiac dysfunction and DPC were treated without MNO (a control group). The pregnant women in the MNO group were treated with normobaric oxygen (oxygen concentration: 99.5%; oxygen volume: 10 L/min) for 30 min once a day (10 times). Results The therapeutic effects in the MNO group were obviously prior to those in the control group (P<0.01), and the healing rates of FA, FCVA and DPC were 95.8%, 84.0%, 95.5% and (37.5%), (34.1%), 23.3% in the MNO and the control groups, respectively. Conclusion MNO was effective and safe for treatment of FA, FCVA and DPC.