高血压病患者血浆中脑利钠肽水平与不同左室构型的相关性研究

STUDY ON THE RELATION BETWEEN BRAIN NATRIVRETIC PEPTIDE CONCENTRATION AND MYOCARDIAL WALL MOTION IN ESSENTIAL HYPERTENSION

目的:分析心脏功能代偿期的高血压病患者不同心脏构型之间的血浆中脑利钠肽(BNP)水平差异,以探讨左室重构可能的机制。方法:心脏收缩功能正常的高血压病患者166例,血压正常对照组87例,应用彩色多普勒超声诊断仪,按Ganau分类法,将高血压病患者组的左心室重构分为正常型、向心性重构型、向心性肥厚型、离心性肥厚型4种构型。对比血浆BNP水平。结果:总体上高血压病组BNP水平高于对照组,按心脏重构分组后,以向心性肥厚组BNP水平升高最显著,向心性构型组和离心性肥厚组次之,而正常构型组虽高于对照组,但差别不明显。结论:尽管高血压病患者尚未出现心功能失代偿,但BNP水平有升高;在不同左心室构型之间,BNP水平不同,提示BNP可能参与了高血压左心室的重构。

Objective:To investigate brain natrivretic peptide (BNP) concentration in the difference myocardial wall motion of essential hypertension. Methods:166 patients with essential hypertension and normal heart function and 87 control subjects were enrolled in this study. According to Canau's categories, the ventricle geometries of patients with hypertension were divided into four groups. Blood pressure and serum concentration of BNP were measured.Result:BNP in patients with hypertension was significantly higher than in control group. After grouped by different myocardial wall motion,the patients with concentric hypertrophy were highest among all the groups (vs control group, P<0.001); and the groups with eccentric hypertrophy, concentric remodeling were secondly highest(vs control group, P=0.001 and P<0.05); Normal geometric pattern was also higher than the controls, but not significant.Conclusion:The results indicate that patients with different myocardial wall motion have different BNP level before heart failure, meanwhile BNP may have an important role in myocardial wall motion in essential hypertension.