先天性无肛畸形儿骶髓的异常改变

Anorectal Anomaly: Neuropathological Changes in the Sacral Spinal cord

采用连续切片的组织学方法，对１０例先天性无肛畸形儿和５例正常新生儿的骶髓标本进行观察，发现１０例畸形儿的末段能髓均存在不同类型的异常改变：６例中央管呈菱形扩大，实质变薄，１例中央管未发育，１例中央管内有一纵行隔膜，另外２例中央管横向扩大。除此之外，骶髓前用内侧群的运动神经元的数目减少，高中位畸形儿和低位畸形儿分别为正常的３４．４％和７０．５％。本研究结果提示，肛门闭锁畸形可能是胚胎早期尾端神经管发育异常所致综合征的病变之一。

The study was carried out on 5 fullterm newborn's bodies with Normal anus and 10 newborn's bodies with anorectal anomaly. On the sacral pinal cord, the serial transverse sections (each 30 um in thickness) were made and stained with Nissle's. The sacral spinal abnormalities were found in the sacral cord of all the 10 bodies with anorectal anomaly. A large diamond-shaped centrel canal was found in 6 cases,the lower part of the central canal undeveloped in 1, saggital septum in 1. widening and flattening of the central canal in 2. Additionally.the average number of motoneurones in the ventral horns of sacral cord in newborns with high or intermediate anorectal anomalies reduced down to 34. 4% of normal number, while in newborns with low anorectal anomaly down to 70. 5%. The results suggest that the anorectal anomaly might be related to caudal neural tube deformity.