恶性肿瘤患儿血清β_2－微球蛋白的测定

The Study of β_2-Microglobulin in the Serum of Children With Malignant Tumor

采用放射免疫分析法对２８例恶性肿瘤、１５例良性肿瘤和５７例正常小儿血清β_２－微球蛋白（β_２－Ｍ）进行测定。结果恶性肿瘤组β_２－Ｍ明显高于其他两组，Ｐ值分别小于０．０５和０．００２；高β２－Ｍ率恶性肿瘤组为５７．４％，良性肿瘤组为１０．７％；术前血清β２－Ｍ高于３．０ｍｇ／Ｌ，提示可能短期复发，预后不良。因此，测定血清β２－Ｍ对小儿恶性实体肿瘤的诊断及预后估计有参考价值。

The level of serum β2-microglobulin was determined by adioimmunoassay in 28 children with malignant tumor, 15 with benign turner and 57 normal children as control. The results showed that the level of serum β2-microglobulin in the malignant group was significantly higher than that in the other two groups; the level of β2-microglobulin was high in 57.14% of the malignant group and in 10. 7% of the benign group. It indicated an unfavorable prognosis that the serum β2-microglobulin was higher than 3.0 mg/L preoperatively. Therefore. This method is valuable for the diagnosis and the prognosis in children with malignant tumor.