疏血通注射液治疗急性缺血性中风临床研究

Treatment of Acute Ischemic Stroke with Shuxuetong Injection

目的观察疏血通注射液治疗急性缺血性中风(脑梗塞)的临床疗效和安全性,并探讨其治疗机制。方法选用发病2周之内的急性脑梗塞、中医辨证属中经络瘀血阻络证的患者,共计464例,随机分组。疏血通治疗组313例,三七皂苷对照组151例,观察中风积分、中医证候积分及血液流变学指标等治疗前后变化。结果治疗3周后治疗组临床治愈35例,显效134例;对照组临床治愈11例,显效54例。2组总有效率分别为91.69%,86.75%,2组比较P<0.05,治疗组优于对照组。临床观察过程中未发现明显的不良反应。结论疏血通注射液用于中风病(脑梗塞)中经络瘀血阻络证急性期的治疗,其主要机理为活血化瘀通络,有较好的临床疗效,且安全性好。

Objective To observe the curative effect and security of Shuxuetong Injection on the acute ischemic stroke (cerebral infarction) and to investigate its mechanism. Method To select 464 cases of AIS (morbidity within 2 weeks) diagnosed by TCM as apoplexy involving meridians and collaterals (AIMC) with the syndrome of blood stasis obstructing collaterals, and divided them randomly into two groups. The treatment group with 313 cases was given Shuxuetong Injection and the control group with 151 cases was given notoginsenoside. The scales of stroke, TCM symptoms and the hemorrheology index were observed before and after the treatment. Result After 3 weeks there were 35 cases cured and 134 had a significant curative effect in the treatment group, and 11 cases cured and 54 had a significant curative effect in the control group. The total effective rate was 91.69 % and 86.75 % in two groups respectively. The result of the treatment group was better than that of the control group (P<0.05). The side effect was not observed in the treatment course. Conclusion The mechanism of Shuxuetong Injection for the treatment of AIS (CI) is to activate blood circulation, resolve stagnation and dredge collaterals. Shuxuetong Injection has a good curative effect and a higher security in clinic .