中药治疗慢性肾炎湿热血瘀证30例自身对照研究

Autonomous Control Study on Treatment of Chronic Nephritis with Chinese Medicine

目的探讨清热利湿、活血化瘀法治疗慢性肾炎湿热血瘀证临床疗效。方法对30例慢性肾炎湿热血瘀证患者进行自身前后对照前瞻性临床研究。分别用复方1、复方2水煎剂口服进行两阶段治疗,各阶段分别治疗12周。观察证候疗效、蛋白尿和血尿疗效。结果第1阶段清热利湿法兼活血化瘀法获得了确切疗效之后,继之第2阶段活血化瘀法兼以清热利湿法可明显提高疗效。证候疗效显示第1阶段疗效对第2阶段疗效起促进作用。蛋白尿疗效优于血尿疗效。结论慢性肾炎湿热血瘀证用活血化瘀法可明显巩固和提高清热利湿法疗效。

Objective To investigate the curative effect of TCM therapy of clearing away heat to drain dampness (therapy 1), and TCM therapy of activating blood to resolve stagnation (therapy 2) on the chronic nephritis diagnosed as TCM syndrome of damp-heat-blood stagnation. Method To make an autonomous control study on 30 cases of the chronic nephritis diagnosed as TCM syndrome of damp-heat-blood stagnation. The Decoctions of Composite Formula 1 and Composite Formula 2 were given orally to the patients in two stages. Each stage was 12 weeks. The curative effect on syndrome, albuminuria and hematuria were observed. Results In the first stage the therapy 1 combined with the therapy 2 had a reliable curative effect, then in the second stage the therapy 2 combined with the therapy 1 significantly improved the curative effect. The curative effect on syndrome in the first stage had a promotion action to that in the second stage. The curative effect on albuminuria was better than that on hematuria. Conclusion Therapy 2 used to treat the chronic nephritis diagnosed as TCM syndrome of damp-heat-blood stagnation has an promotion effect on therapy 1.