摘要
我们用葡萄糖耐量试验对33例Ⅱ期、Ⅲ期高血压病患者和25例正常对照者的研究发现:口服葡萄糖后30min、60min、120min和180min时前者的血糖浓度显著高于后者(P<0.02,P<0.01,P<0.005,P<0.005)。空腹、服糖后120min、180min时前者的血清胰岛素浓度显著高于后者(P<0.05,P<0.01,P<0.02),这是典型的胰岛素抵抗。高血压病患者空腹血胰岛素浓度及胰岛素曲线下面积与动态的收缩压、舒张压、平均动脉压呈线性正相关。
Abstract Thirty three subjects with second to third stages of essential hypertension and 25 normotensive subjects were selected for study. OGTT (Oral glucose tolerance test) and serum insulin were tested for the presence of insulin resistance. It was found that the hypertensive persons had higher serum glucose levels at 30 to 180 minutes than did normotensive persons (P<0. 02, P<0.01 P<0. 005 , P<0. 005 ). The serum insulin levels in the former was markedly higher than in the latter at baseline and 120 to 180 minutes (P<0. 05 , P<0.01 ,P<0. 02). It is suggested that there is typical insulin resistance in hypertensive patients. Baseline serum insulin level and area under insulin curve correlated to ambulatory systolic , diastolic and mean arterial pressure in hypertensive patients.
出处
《中华心血管病杂志》
CAS
CSCD
北大核心
1994年第5期373-374,共2页
Chinese Journal of Cardiology