摘要
３０例行心脏直视手术病人随机分为对照组和抑肽酶用药组。于麻醉后、主动脉阻断开放时、体外循环结束后１０ｍｉｎ、２ｈ和术后２４ｈ，分别观察血小板计数、血小板聚集率、ＴＸＢ２、６－ｋｅｔｏ－ＰＧＦ１α、ⅧＲ：Ａｇ、ＡＴⅢ：Ａ与ＦＤＰ，并记录术后２４ｈ纵隔心包引流量。结果表明，大剂量抑肽酶可增加术后血小板功能、抑制纤溶、提高术后凝血因子含量等，从而减少了术后出血。
Thirty patients were divided into two groups.One group received high-dose aprotinin during extracorporeal circulation. The platelet counts, the platelet aggregation function, TXB2, 6-keto-Fgla, AtIIIA FDP were determined at five time-points, and the first 24 hour postoperative blood loss was recorded.The results showed high dose aprotinin can prevent hyperfibrinolysis, protect the platelet function and the amount of postoperative blood loss.
出处
《中华胸心血管外科杂志》
CSCD
北大核心
1994年第1期30-32,共3页
Chinese Journal of Thoracic and Cardiovascular Surgery
关键词
体外循环
抑肽酶
出血
凝血机制
Cardiopulmonary bypass
Aprotinin
Postoperative bleeding
FDP
Platelet function
