子宫内膜癌患者血清层粘连蛋白水平与预后因素的临床研究

Clinical research of the relation between laminin level in blood serum and prognosis factor in carcinoma of corpus uteri patients

目的:测定子宫内膜癌患者血清层粘连蛋白(laminin,LN)水平及其变化与肿瘤切除的相互关系。方法:用放射免疫法测定16例子宫内膜癌、66例内膜正常的妇科良性疾病患者血清LN含量。结果:子宫内膜癌患者血清LN明显高于内膜正常各良性疾病组及子宫内膜增殖症组(P<0.05);手术切除肿瘤后,血清LN水平显著下降(P<0.01);内膜癌肌层浸润程度与术前血清LN水平及术后LN下降程度有密切关系。结论:血清LN水平的变化与子宫内膜癌的浸润过程及复发可能相关;血清LN水平及其变化对子宫内膜癌的诊断及预后的监测有一定的意义。

Objective:To determinate the laminin level in carcinoma of corpus uteri patients and the relation between its change and the effect of tumor resection. Methods: Laminin level in 16 instances of carcinoma of corpus uteri and 66 instances of gynecologic benign diseases with normal endometrium were determined by radio immunity. Results: The laminin level in carcinoma of corpus uteri patients was significantly higher than that of each benign disease bundle with normal endometrium( P <0.05) and endometrium proliferation bundles.The laminin level significantly decreased after the immunity operational resection of the tumor ( P <0 01).The degree of myometrium infiltration of endometrium carcimoma had intimate relation with the degree of preoperative laminin level and the decent degree of postoperative laminin level. Conclusion:The laminin level may have relation with the infiltrate process and relapse of the carcinoma of corpus uteri. The laminin level and its changes have certain value for diagnosis and prognosis in monitoring carcinoma of corpus uteri.