硝酸甘油与美托洛尔联用对心绞痛疗效的评价

Evaluation of the effects of nitroglycerin combined with metoprolol in the treatment of patients with angina of coronary heart disease

目的:探讨硝酸甘油与美托洛尔联用对心绞痛的疗效.方法:将 68例心绞痛患者随机分为两组,治疗组(A组)34例,应用硝酸甘油10～15mg静脉滴注,1次/d,并加服美托洛尔12.5～50mg,2次/d;对照组(B组)34例,单用硝酸甘油10～15mg静脉滴注,1次/d.结果:两组心绞痛疗效总有效率分别为94.1%和70.6%,差异非常显著(P<0.01);两组心电图(ECG) ST-T改善的总有效率分别为91.2%和67.6%,差异非常显著(P<0.01).治疗组治疗后心率较治疗前明显降低(P<0.01).结论:硝酸甘油与美托洛尔联用对心绞痛有协同治疗作用,疗效较单用硝酸甘油为佳.

Objective: To explore the effects of nitroglycerin combined with metoprolol in the treatment of patients with angina of coronary heart disease. Methods: Sixty-eight patients with angina of coronary heart disease were randomly divided into two groups: group A ( n =34) and group B ( n =34).The patients of group A received 10~15mg dialy of nitroglycerin intravenously plus 12.5~50mg daily twice of metoprolol orally;the subjects of group B received 10~15mg dialy of nitroglycerin intravenously alone. Results:The total effective rate in the two groups were 94.1%and 70.6% and ECG of ST-T were 91.2% and 67.6% (χ 2=5.75, P <0.01).The significant difference was found between the two groups (χ 2=6.47, P <0.01) .The heart rates were greatly reduced in group A after treatment( t =4.10, P <0.01).Conclusion:Nitroglycerin plus metoprolol has a synchronous action in the treatment of patients with angina of coronary heart disease and better than that nitroglycerin alone.