鳞状细胞癌抗原在食管癌临床的应用

^Study of Serum Squamous Cell Carcinoma Antigen in Patients with Esophageal Carcinoma

采用微粒酶免疫荧光法测定了４０例食管癌和７例术后复发病人的血清鳞状细胞癌（ＳＣＣ）抗原含量，取２０例正常人，１５例食管良性病人和１５例腺癌病人作对照。结果表明，食管癌和术后复发病人的血清ＳＣＣ抗原含量显著高于正常人、良性病人和腺癌病人（Ｐ值分别＜０．００１、０．０１和０．０５），ＳＣＣ抗原与临床病期、细胞的分化程度有关。这提示血清ＳＣＣ抗原是食管癌理想的肿瘤标志物，对食管癌的诊断、预示术后复发和判断食管癌的恶性程度都有重要的临床价值。

Serum squamous cell carcinoma (SCC) antigen was examined by the method of microparticle enzyme immunoassay in 40 patients with primary esophageal carcinoma. Twenty normal subjects, 15 patients with benign esophagnl diseases and 15 patients with esophageal adenocarcinoma were used as control group. Serum SCC antigen levels in the patients with esophageal SCC were higher than in the patients with benign diseases (P<0.01), adenocareinoma (P<0.05) and normal subjects (P<0.001).Serum SCC antigen level was related to clinical stages and degree of differentiation of the esophageal SCC. The result suggests that serum SCC antigen level is a good SCC marker. It may play an impoftant role in the diagnosis of esophageal SCC.degree of differentiation and its recurrence