病毒性肝炎和再生障碍性贫血发病关系的临床流行病学研究

CLINICAL EPIDEMIOLOGIC STUDY ON THERELATIONSHIP BETWEEN VIRAL HEPATITIS ANDAPLASTIC ANEMIA

病毒性肝炎相关性再生障碍性贫血（ＨＡＡＡ）与何种肝炎病毒相关联，至今尚未明确。我们采用临床流行病学研究方法来探讨肝炎和再生障碍性贫血（再障）发病之间关系。本研究采用１：２配对医院内病例对照研究方法调查１６０例获得性再障，并且在上海市静安区４８３５２７人群中前瞻性随访４年（１９８６～１９８９年）肝炎和再障的发病率变迁，同时对临床上确诊为ＨＡＡＡ的１４例患者进行肝炎病原的血清学分析。本研究表明，无论在病例对照研究和肝炎病原血清学分析中都不能证实甲型肝炎和ＨＡＡＡ发病有关。上海市静安区甲型肝炎暴发流行前后再障发病率亦无变化。本资料仅证实２例ＨＡＡＡ系由乙型肝炎引起。大多数ＨＡＡＡ病例可能由非甲非乙型肝炎引起。

he agents responsible for the hepatitis in case of he-patitis associaed aplastic anemia (HAAA) have not welldefined. The study was carried out by using clinical epi-demiologic study to seek the relationship between thehepatitis and aplastic anemia (AA). A 1 ; 2 matched andhospital based case control study was conducted among160 cases of acquired AA , a prospective study was car-ried out among 483527 population at Jingan district ofShanghai to follow the incidences of hepatitis and AA for4 years (1986 ￣ 1989) , and a serologic study on viralhepatitis was performed among 14 cases of HAAA. Ourstudy showed that no relationship berween hepatitis Aand HAAA could be found in case control study andserologic study. The incidence of AA was not changedbefore and after an outbreak of hepatitis at Jingan dis-trict of Shanghai. Only two cases of HAAA were causedby hepatitis B. The most cases of HAA were caused bynon-A , non-B hepatitis.