光照疗法对新生儿红细胞谷胱甘肽还原酶活性的影响

THE EFECT OF PHOTOTHERAPY ON THE ACTOVITYOF GLUTATHIONE REDUCTASE IN RED BLOOD CELLS OF NEONATES

作者对光照疗法（光疗）前及光疗后于口服维生素Ｂ＿２（４３例）和不予口服维生素Ｂ＿２（１７例）的黄疸新生儿的红细胞谷胱甘肽还原酶（ＧＲ）的活性进行了动态观察。结果显示，接受短期光疗的黄疸新生儿其红细胞ＧＲ活性较光疗前的ＧＲ活性有显著下降，光疗后予口服维生素Ｂ＿２可使下降的红细胞ＧＲ活性回升，而不予补充维生素Ｂ＿２者的红细胞ＧＲ活性继续下降。光疗的时间越长，红细胞ＧＲ活性的下降越明显，补充维生素Ｂ＿２使红细胞ＧＲ活性回复到正常水平所需的时间也越长。短期光疗也可引起体内维生素Ｂ＿２的降解，导致红细胞ＧＲ活性的下降，为避免因红细胞ＧＲ活性下降引起的红细胞额外破坏，对接受光疗的黄疸新生儿常规补充维生素Ｂ＿２的是必要的。

n order to investigate the impact of short-term pho-totherapy on the activity of glutathione reductase(GR)in red blood cells (RBC)of neonates,the GR activity inRBC of jaundiced neonates before and after phototherapyand the effect of post-phototherapy with and without ad-ministration of riboflavin were observed. The resultsshowed that the GR activity in RBC of jaundicedneonates was decreased significantly after short-termphototherapy,and the administration of riboflavin afterphototherapy could recover the GR activity. If riboflavinwas not given after phototherapy,the decreased GR ac-tivity would last for a longer time. The longer pho-totherapy was manipulated,the more the GR activitywas decreased, and the longer the time was required forthe recovery of GR activity by administering riboflavin.The results indicated that short-term phototherapy couldcause the degradation of riboflavin in vivo,and conse-quently resulted in the decrease of GR activity in RBC.Therefore it is recommanded to give riboflavin orally tothe jaundiced neonates undergoing phototherapy.