2型糖尿病合并脑梗塞患者血浆脂联素的变化研究

Changes of plasma adiponection in patients with type2 diabetes mellitus associated with cerebral infarction

目的探讨2型糖尿病患者及其合并脑梗塞患者中血浆脂联素水平的变化。方法选取2型糖尿病患者83例(A组)、合并脑梗塞患者20例(B组)、健康对照者35例(C组)作为研究对象。测定受试者血浆脂联素水平、血压、体重等,比较脂联素水平的改变,以及与其它因素的相关性。结果A组血浆脂联素水平明显低于C组(P<0.01),B组血浆脂联素又明显低于A组(P<0.01)。在糖尿病患者中,血浆脂联素与收缩压(SBP)呈负相关(r=-0.309,P<0.01)。结论对2型糖尿病患者及2型糖尿病合并脑梗塞者检测血浆脂联素水平具有临床诊断价值。

Objective To assay the changes of the plasma adiponection in patients with type2 diabetes mellitus and with type2 diabetes mellitus associate d with cerebral infarction. Methods 83 patients with type2 diabetes m ellitus (group A), 20 patients with type2 diabetes mellitus associated with cere bral infarction (group B) and 35 healthy subjects (group C) were chosen in the s tudy. In all of the selected individuals, the levels of plasma adiponection, blo od pressure and weight had been detected. Comparison of adiponction levels and its correlation with other factors had been done. Results Levels of plasma adiponection in group A was significantly lower than that in gr oup C (P<0.01), and plasma adiponection in group B was significantly lower t han that in group A (P<0.01). In patients with diabetes mellitus, plasma adi ponection had negative correlation with SBP (R=-0.309, P<0.01). Conclusion The determination o f plasma adiponection is valuable in clinical diagnosis of type2 diabetes mellit us and type2 diabetes mellitus associated with cerebral infarction.