卵巢癌患者血清TGF-α、TGF-β_1和CA125的检测及意义

Significance of the determination of serum TGF-α, TGF- β_1 and CA125 in patients with ovarian cancer

目的探讨卵巢癌患者血清中TGF-α、TGF-β1和CA125与卵巢癌患者预后的相互关系。方法采用放射免疫测定法和酶联免疫吸附法检测57例卵巢癌患者(恶性组)术前术后血清中TGF-α、TGF-β1和CA125水平,设52例卵巢良性肿瘤患者(良性组)及55名正常妇女(正常组)为对照组。结果恶性组术前TGF-α、TGF-β1、CA125水平比良性组及正常组明显增高(P均<0.01);术后TGF-α、CA125水平明显降低,TGF-β1水平明显升高(P均<0.01)。结论检测卵巢癌患者血清中TGF-α、TGF-β1和CA125水平对判断患者预后有重要价值。

Objective To investigate the re la tionship between serum TGF-α, TGF-β_1, CA125 and the prognosis in patients wi th ovarian cancer. Methods A radioimmunoassay and an ELISA techni que were used to detect the levels of TGF-α, TGF-β_1 and CA125 before and aft er operation in 57 patients with ovarian cancer (the malignant group), 52 patien ts with benign ovarian neoplasm (the benign group) and 55 healthy subjects (the normal group) were selected as the con trast. Results In the malignant group, the TGF- α, TGF-β_1 and CA125 levels before operation were higher than those in the benign group and the normal group (all P<0.01); after operation, TGF-α, CA1 25 levels decreased significantly , TGF-β_1 elevated significantly (all P<0.01). Conclusion Serum TGF-α, TGF-β_1 and CA125 is predictable for the progno sis of ovarian cancer.