安徽省回族居民中两例HbDPunjab纯合子一级结构分析

PRIMARY STRUCTURE ANALYSIS OF TWO Hb DPUNJAB HOMOZYGOTES FOUNO IN ANHUI PROVINCE

继青海、甘肃、新疆、河南等地发现ＨｂＤＰｕｎｊａｂ杂合子后，我们又在安徽省阜阳地区发现两例ＨｂＤ纯合子，经一级结构分析，确诊为ＨｂＤＰｕｎｊａｂβ１２１（ＣＨ＿４）Ｇｌｕ→Ｇｌｎ。这一发现为探讨该地区回族中异常Ｈｂ发生率高的原因，研究各民族的亲缘关系以及Ｈｂ变异对人类健康与发展的影响提供了遗传学资料。

wo Hb D Homozygotes were found in Fuyang regionof Anhui Province. Primary structure analysis confirmedthat they were Hb D Punjab β 121 (GH_4) Glu→Gln.The significance of this finding was discussed.