摘要
用荧光灯光源(18175±300lx)照射大鼠视网膜,经测定视网膜丙二醛(MDA)含量判断视网膜脂质过氧化(LPO)水平。结果发现:2小时光照3天后视网膜MDA含量增高,5天后逐渐下降,8天后接近正常。分别用维生素E和β胡萝卜素抗损伤,表明两种药物均有抗光损伤LPO作用,且与用药剂量、时间有关。
AbstractContinuous illumination of 18 175 lx caused de-generation of the retinal photoreceptor cells in albinorats,accompanied by increase of malondialdehvde(M DA)3 days after the light exposure.The M DA de-creased gradually to return to normal 8 days after theexposure.Administration of vitamh E or β-carotineboth prevented the increase of retinal lipid peroxidewith amelioration of the photic injury to the retinalstructures,though the effects were closely related tothe dosage and time of medication.
出处
《中华眼科杂志》
CAS
CSCD
北大核心
1994年第2期125-127,共3页
Chinese Journal of Ophthalmology