兔眼晶体机械伤后谷胱甘肽过氧化物酶活性和丙二醛含量动态变化

The dynamic changes of glutathione peroxidase activityand malondialdehyde level in experinlental traumatic cataract of rabbit

兔眼晶体机械性损伤后不同时间测定谷胱甘肽过氧化物酶（ＧＳＨ－ＰＸ）活性和丙二醛（ＭＤＡ）含量，其结果表明：伤后８小时至２１天内，ＧＳＨ－ＰＸ活性较对照组明显降低（Ｐ＜０．０１），而ＭＤＡ含量则显著升高（Ｐ＜０．０１）。提示晶体外伤后抗自由基及脂质过氧化作用降低，是导致ＧＳＨ－ＰＸ活性下降、ＭＤＡ含量升高和白内障形成的重要原因。

AbstractGlutathione peroxidase activity(GSH-PX)andmalondialdehvde(MDA)level of experimental trau-matic cataract in rabbit were determined at various in-tervals after needling。 GSH-PX activities decreased in the lens after perforated trauma from 8 hours to 21 days,meanwhile the MDA level increased markedly.The results demonstrate that free redicals are involved in the formation of traumatic cataract.