基于复杂网络理论的代谢网络结构研究进展

Progress of Metabolic Network Structure Based on Complex Network Theory

后基因组时代研究的一个重要内容就是在系统生物学的基础上对多种分子和基因相互作用网络进行分析,理解生物系统是如何从单个构造模块的基础上组织起来的。近几年,复杂网络理论得到了迅速发展,其理论方法在生物网络的研究中得到了广泛应用。一些学者运用该理论方法研究了大量有关代谢网络的结构组成以及网络中子集团的层次组成关系,并获得了一些有意义的结果。这些结果对生物功能的预测具有一定的指导作用。对近几年来有关这方面的进展作简要综述。

One of the most important impacts in the postgenomic times is to analyze the interactions among molecules and genes based on systematic biology, to understand how the biology system is organized with the singular modular. Recenty, a complex network theory has been developed fast and applied in biologic network widely. Some researchers have applied this theory to study metabolic network' s structure organization, hierarchical structure of its clusters and got some instructing results. These results will play an important guiding role in biological functional prediction. The progress in these fields were reviewed.