IgG重链同种异型Gm同肝癌的相关分析

THE ANALYSIS OF ASSOCIATION BETWEEN ALLOTYPE (Gm) OF IgG HEAVY CHAIN AND THE OCCURRENCE OF PRIMARY HEPATO-CELLULAR CARCINOMA

对９５例肝癌患者、１８４例其他肿瘤患者、１９３例乙型肝炎患者，９４８例正常人进行了ＧＭ分型分析。结果显示，Ｇｍ（ｚａｘｆｂ０ｇ）与肝癌有关，连锁不平衡参数的相对△为５５．５％，Ｐ＜０．０１，单倍型Ｇｍ１，２，３，１１，２１的频率增高。可以认为，原发性肝癌的发生中存在着一种免疫学背景。

This article collected 95 cases of liver cancer,184 cases of cancers other than liver one, 193 patients with hepatitis B and 948 general population. Their allotypes(Gm)have been typed, We found that Gm(zaxfb0g)had close association with the occurrence of liver cancer.The relative △ of disequilibrium parameter reached 55. 5% , P<0. 01. It shows that the frequency of haplotype Gm1,2,3,11,21 increases, too. We believe that among others there exists an immuno-genetic background in the development of primary hepatocellular carcinoma.