吸烟致组织移植血循环危象的临床与实验研究

Cigarette smoking and circulatory crisis in tissue trans-fer

２例足趾移植和１例肌皮瓣在吸烟后发生血循环危象，造成２例手术失败，１例经积极抗凝解痉治疗后成活。实验研究证实吸烟对大鼠血管吻合口内皮细胞愈合过程有不良影响，吸烟组血管吻合后５～１０天，内皮细胞生长率仅占１６％～３２％，血小板吸附占８％～１０％，而正常组分别为７５％－１００％及０％。文章讨论了吸烟引起血循环危象的机制和特点。

irculatory cnsis occurred in 2 cases oftoe-to-hand transfer and 1 case of musculocutaneousfree flap after smoking. Two of them failed and I sur-vived after exceeding antispasm and antithrombosistreatment. Experimental studies showed harmful in-fluences of cigarette smoking on endothelial healingprocess at the vascular anastomosis site, which wascovered by endothelial cells in 16%- 32% andplateletin 8% - 10% of the smoking group 5-10 daysafter operation, but in 75%-100% and 0% of thenornial group. The mechanism and characteristics ofcirculatory crisis caused by cigarette smoking are dis-cussed.