摘要
北京协和医院糖尿病门诊长期随访的280例胰岛素依赖型糖尿病中,26.8%有糖尿病的家族聚集。发生糖尿病的亲属中,68.0%为一级亲属,28.0%为二级亲属,4.0%为三级亲属。对13个胰岛素依赖型糖尿病家庭的87名一级亲属进行的HLA分型表明,胰岛素依赖型糖尿病易感性与HLA基因相关,且为多基因遗传病。
n 280 patients with IDDM,
the positive familyhistory of diabetes was 26.8% of IDDM probands.The prevalence of diabetes in
relatives was 68% in firstdegree relatives, 28% in second degree relatives, and4% in third degree
relatives. HLA typing of 87 mem-bers in 13 pedigrees with IDDM was perfornied. Thesedata
support the hypothesis that IDDM is amultigenic hereditary disorder.
出处
《中华医学杂志》
CAS
CSCD
北大核心
1994年第1期16-18,共3页
National Medical Journal of China