摘要
目的:探讨肾上腺髓质素(AM)、降钙素基因相关肽(CGRP)在妊高征发病中的作用及其临床意义。方法:采用放射免疫法测定55例妊高征患者及30例正常妊娠妇女血浆AM、CGRP浓度。结果:①妊高征患者血浆AM显著高于正常妊娠组(P<0.01),CGRP浓度则明显下降(P<0.05),妊高征各组间比较差异具有显著性(P<0.05);②妊高征患者血浆AM与平均动脉压(MAP)呈显著正相关(r=0.76,P<0.01),CGRP与MAP则呈负相关(r=-0.54,P<0.05);③妊高征患者血浆AM浓度与CGRP浓度呈负相关(r=-0.65,P<0.05)。结论:AM、CGRP共同参与妊高征的病理生理过程,联合检测其血浆浓度可以作为监测PIH病情的重要指标。
Objective:To assess the roles of plasma AM and CGRP levels in pathogenesis of pregnancy-induced hypertension(PIH) and its clinical value.Methods:Plasma AM and CGRP levels were mesured by radioimmunoassay in 55 patients with PIH and 30 normal pregnant women.Results:①The levels of AM in PIH were significantly higher than that in controls (P<0.01),but CGRP decreased obviously (P<0.05).②There were notable positive correlation between plasma AM levels and mean arterial pressure(MAP) in PIH(r=0.76,P<0.01),however,there was a negative correlation between plasma CGRP and MAP(r=-0.54,P<0.05).③A significant negative correlation between AM and CGRP(r=0.65,P<0.05).Conclusion:AM and CGRP could play an important role in pathophysiological process of PIH.Associated detection of plasma concentration may be used as indicators for the severity of PIH.
出处
《中国妇幼保健》
CAS
北大核心
2005年第12期1464-1465,共2页
Maternal and Child Health Care of China
关键词
妊娠高血压综合征
肾上腺髓质素
降钙素基因相关肽
Pregnancy-induced hypertension syndrome
Adrenomedullin
Calcitonin gene-related peptide