肺表面活性物质在新生儿转运中稳定呼吸道作用的临床探讨

Pulmonary surfactant as a valuable therapy for airway maintenance during neonatal transportation

目的:探讨转运前在基层医院使用肺表面活性物质(PS)对转运过程中气道的稳定作用。方法:34例高危早产儿(实验组)转运前气管内滴注PS,与34例须转运但未使用PS的早产儿(对照组)进行前瞻性临床对照研究。结果:实验组与对照组比较,途中出现血氧饱和度下降的例数显著降低,氧分压、血氧饱和度、动脉/肺泡血氧分压比值显著增加;氧疗时间、机械通气时间和住院天数显著减少(P<0.05)。结论:转运前在基层医院使用PS,可稳定早产儿气道,保证转运质量,改善早产儿临床症状,缩短氧疗时间、机械通气时间和住院天数。

Objective:To investigate the efficacy of pulmonary surfactant (PS) replacement therapy for airway maintenance during neonatal transportation.Methods:A prospectively study was made for 34 premature infants administered with PS before transportation (experimental group) and 34 premature infants without PS administration before transportation (control group).Results:Compared with control group, the experimental group had a significantly lower desaturation during transportation, significantly decreased mechanical ventilation duration, supplemental oxygen therapy duration and hospitalized period.Conclusion:It is a valuable method to have PS replacement therapy for airway maintenance during neonatal transportation,which can level off neonate’s airway,guarantee transportation quality,improve their clinical symptoms,shorten time for oxygen therapy and mechanical ventilation and duration.