胃肠间质瘤49例的诊治和病理分析

A Clinicopathological Study on 49 Cases of Gastrointestinal Stromal Tumor(GIST)

目的探讨胃肠间质瘤(gastrointestinalstromaltumorGIST)临床和病理特点。方法回顾分析我院1996年至2003年49例胃肠间质瘤临床和病理资料。结果本组胃间质瘤26例,小肠间质瘤17例,结肠间质瘤4例,直肠间质瘤2例,平均中位年龄57岁。全组病例均行根治性局部切除手术治疗,病理结果:良性11例,交界性28例,恶性10例。术后随访41例,7例死亡,其余均生存。结论肿瘤的良、恶性与肿瘤的大小、核分裂像密切相关,根治性局部切除术是GIST的主要治疗手段。

Objective To investigate the clinicopathologic features of GIST. Methods The clinicopathological data of 49 cases of primary GIST from 1996 to 2003 were reviewed retrospectively. Results All patients were adults, age range 26-78 years(mean 57 years). The tumors were situated in the stomach(26 cases), small intestine (17cases), colon(4cases) rectum(2cases). All cases were treated by radical operation. Benign tumors accounted for 11cases, borderline tumors 28cases, malignant tumors 10cases. Among follow up of 41 cases, 6cases died, 35 cases were alive without tumor. Conclusion The malignancy of GIST was correlated with the size of tumors, nuclear mitotic activity of tumors and ulcer formation significantly(P<0.05). The chief remedy of GIST is radical operation.