血中胆红素及低密度脂蛋白(LDL-C)的测定对心血管疾病的意义

The significance of the determin of serum bilirubin and low density lipoprotein(LDL-C) for the cardiovascular disease

目的研究心血管病人血中胆红素与低密度脂蛋白(LDL-C)浓度的变化,探讨变化对心血管疾病诊断与治疗的意义及二者是否相关。方法对47例心血管病组(冠心病组26例,心衰组21例)的总胆红素(TB),直接胆红素(DB),间接胆红素(IB)及低密度脂蛋白进行测试,并分别与对照组(27例)各项值进行比较。结果心血管病各组的总胆红素,直接胆红素,间接胆红素各值均低于对照组(P<0·05),心血管病各组的低密度脂蛋白较对照组增高(P<0·05),且各组间LDL-C与胆红素具有相关性。结论血清胆红素浓度降低使体内抗氧化活性减弱,可能引起低密度脂蛋白氧化修饰形成OX-LDL增多,动脉粥样硬化形成增多,从而促进冠心病等各种心血管疾病的发生。且LDL-C与胆红素呈负相关。

Objective To study the change of serum concentration of bilirubin and low density lipoprotein(LDL-C), and explore the significance for the diagnose and treatment with cardiovascular disease. Methods To examine the level of serum total bilirubin, direct bilirubin, indirect bilirubin and low density lipoprotein(LDL-C) of 47 cases cardiovascular disease patients(concluding coronary artery disease of 26 cases and heart failture of 21 cases) and the 27 cases control group, then campanison was done between the two groups. Results The concentration of total bilirubin and direct bilirubin in cardiovascular disease were lower than those in the control(P<0.05), the concentration of LDL-C in cardiovascular disease were higher than those in the controls(P<0.05), and the bilirubin and LDL-C has correlation in every group. Conclusion Lower serum bilirubin concentration possibly reduce the artivities of antioxidant. It is possible to expedite that low density lipoprotein peroxidation and lower serum bilirubin is associated with increased risk for coronary artery disease and other cardiovascular disease, and LDL-C and bilirubin has the negative correlation.