肾性高血压和IgA肾病病人红细胞钠／锂逆转运率的变化

Red-cell sodium-lithium countertransport in patientswith IgA nephrology and renal hypertention

应用改良的Ｃａｎｅｓｓａ氏法，测定了２１例ⅠｇＡ肾病病人（ⅠｇＡＮ）、１３例肾实质性高血压病人（ＲＨＴ）的红细胞钠／钾逆转运率（ＲＢＣＮａ＋／Ｌｉ＋ＣＴ）活性，并与２３例正常人（ＮＯＲ）及ｌｌ例原发性高血压病人（ＥＨＴ）进行对照。结果：（１）ＥＨＴ及其有高血压家族史的ＥＨＴ病人ＲＢＣＮａ＋／Ｌｉ＋ＣＴ均明显高于正常人；（２）伴高脂血症的ＲＨＴ病人ＲＢＣＮａ＋／Ｌｉ＋ＣＴ明显升高；（３）单纯高脂血症及高脂血症伴高血压的ⅠｇＡＮ病人ＲＢＣＮａ＋／Ｌｉ＋ＣＴ明显高于正常人；（４）３４例肾脏病病人ＲＢＣＮａ＋／Ｌｉ＋ＣＴ与血清胆肥固醇水平呈正相关。结果提示ＲＢＣＮａ＋／Ｌｉ＋ＣＴ活性增高是原发性高血压的“遗传标志”；部分肾性高血压病人及ⅠｇＡＮ病人的ＲＢＣＮａ＋／Ｌｉ＋ＣＴ活性增高可能与伴发高脂血症有关。

o find changes in activity of red-cellsodium-lithium counter transport (RBC Na+/Li+CT) in IgA nephrology (IgAN) and renalhypertension (RHT), we measured the activity of RBCNa+ / Li+CT in 21 patients with IgAN and 13 patientswith RHT and compared it with that in 23 noimalpersons and 17 essential hypertension (EHT) patientsby improved Canessa's method. RBC Na+ / Li+CT ac-tivity in the EHT patients and EHT patients with posi-tive family history was significantly higher than that innornial group. The activity of RBC Na+/ Li+CT inthe hyperlipidemic RHT patients was increased ascompared with the normal group. The activity of RBCNa+/ Li+CT in IgAN patients with hyperlipidemiaand hyperlipidemic hypertensive IgAN patients wassignificantly higher than that in normal group. Therewas positive correlation between the activity of RBCNa+ / Li+CT and serum cholesterol level in 34 patientswith renal disease. The results indicate that enhancedactivity of Na+ / Li+ CT is a genetic marker for EHTpatients, and hyperlipidemia is probably related to theenhanced activity of RBC Na+/ Li+ CT in parts ofRHT patients and IgAN patients.