脑梗死患者血浆C反应蛋白的变化及降脂干预研究

The Change of C-Reactive Protein in Plasma of Patients with Cerebral Infarction and the Intervention Research of Simvastatin

目的观察脑梗死(CI)患者血浆C反应蛋白(CRP)含量的变化,以及辛伐他汀降脂治疗对其的影响。方法CI患者110例,随机分为辛伐他汀组(56例,在常规治疗基础上加用辛伐他汀)和常规组(54例)。采用免疫浊度法在发病后不同时点动态观察血浆CRP含量。另设30例门诊健康体检者为对照组,监测血浆CRP浓度。结果CI后血浆CRP含量显著升高。治疗后,辛伐他汀组CRP显著降低(P<0.01);常规组无显著下降;2组比较有显著差异(P<0.01)。结论CRP参与并影响了CI后的病理生理过程;辛伐他汀可降低CRP含量。

Objective To observe the change of C-reactive protein (CRP) content in plasma of patients with cerebral infarction (CI),and to evaluate the therapeutic effect of simvastatin on its change. Methods 110 cases of CI were randomly divided into simvastatin group (simvastatin is used with general therapy) and general group.CRP content in plasma were observed by immune turbidity method at different time,while 30 healthy persons were observed as control group. Results CRP content in plasma increased significantly with CI.After treatment,CRP was significantly decreased in simvastatin group (P<0.01) and was not significantly changed in general group,while CRP had significant difference between simvastatin group and general group (P<0.01). Conclusion CRP interfere with the complex process of pathologic after CI.Simvastatin has therapeutic action on CI partly by depending on affecting content of CRP in plasma.