光照疗法所致新生儿溶血的机理及其预防

Mechanism and prevenhon of hemolysis of jaundicedinfants in phototherapy

观察了接受短时间（≤４８小时）光照疗法（光疗）治疗的高胆红素血症患儿红细胞谷胱甘肽还原酶（ＧＲ）活性的改变，光疗可使红细胞谷胱甘肽还原酶活性下降，使高胆红素血症患儿溶血加剧。红细胞谷胱甘肽还原酶活性下降是由于维生素Ｂ２的光降解，致体内维生素Ｂ２不足所致。补充维生素Ｂ２可以纠正红细胞谷胱甘肽还原酶活性，从而防止光疗造成的溶血副作用。因此高胆红素血症新生儿在光疗期间常规补充维生素Ｂ２是必要的。

t has been reported that the prolongedphototherapy results in decreased glutathionereductase (GR) activity in red blood cells. We foundshort-term phototherapy had the same side-effect.Besides it aggrevates hemolysis of newborns during thetherapy. This side-effect can be prevented by oral ad-ministration of Vit B2. Eighteen jaundiced infants whowere given Vit B2 smg three times a day during thephototherapy, and the control group of 16 patientswere not given Vit B2. The results showed that the de-crease of hemoglobin and the time of jaundice disap-pearance during the photoherapy were more favoura-ble in the oral Vit Bz group than those of the control.These results indicated that the short-teimphototherapy not only results in decreased GR activityin red blood cell , but also results in hemolvsis of thenewborn. This side-effect can be prevented by oraladministration of Vit B2.