摘要
目的研究纤溶酶原激活物抑制剂-1(PAI-1)基因多态性对脑梗死发病的影响。方法对52例脑梗死患者和31名正常对照者进行PAI-14G/5G基因多态性的检测,同时进行血浆PAI-1活性测定。结果通过基因多态性的检测,脑梗死患者4G/5G基因型的比例明显高于正常对照组(P=0.021)。在PAI-1活性测定中,脑梗死组高于对照组(P<0.01)。脑梗死和正常对照组中4G/5G基因者的PAI-1活性均大于4G/5G基因型个体(P<0.01或P<0.05)。结论PAI-1及4G/5G基因多态性可能在脑梗死的发病中起重要作用。
Objective To study the effect of PAI-1 4G/5G polymorphism on cerebral infarction (CI), Methods PAI-1 4G/5G polymorphism and PAI-1 activity were measured in 52 CI patients and 31 controls. Results The distribution of PAI-1 4G/4G genotypes in the patients was more than that in controls (P= 0. 021). PAI-1 activity in patients was significantly higher than in controls(P <0. 01). PAI-1 activity in both patients and controls with 4G/4G genotype was highev than that in those with 4G/5G genotype. Conclusion PAI-1 as well as PAI-1 4G/5G polymorphim might play an important role in pathogenesis of CI.
出处
《血栓与止血学》
2005年第3期112-113,共2页
Chinese Journal of Thrombosis and Hemostasis
