摘要
将30例二尖瓣病变行开心手术患者随机分为3组:GⅠ,11例,心停搏液中不加人参皂甙;GⅡ,11例,心停搏液中加入参总皂甙;GⅢ,8例,心停搏液中加入参皂甙Rb。术中进行食管超声监测心功能,示GⅡ及GⅢ组术后心功能改善优于GⅠ。在阻断主动脉前(缺血前期),解除阻主动脉前即刻(缺血期)及再灌45分后(再灌期)分别取心肌作电镜检奄,每组6例,结果显示GⅠ组的线粒体损害明显重于GⅡ及GⅢ组。结论认为人参皂甙加于心停搏液中较只用心停博液者对心肌缺血再灌损伤有明显防护作用;且人参总皂甙优于人参皂甙Rb。
hirty mitral valvular surgical
patients were ran-domly divided into three groups for study of protectiveeffects of Ginsenside
on nivocardiac ischemic andreperfusion injuries.In GI,11 patients (controls),noGinsenside was
used,in GⅡ,11,Ginsenside in totalwas added uito the cardioplegic solusion made in
ourhosprtal, and in GⅢ,8,instead of Ginsenside in totalGinsenside Rb was added. During
operation compara-tive studies were made of preand postoperative cardiacfunctions with
intraoperative transesophageal echocar-diography and utrastructures of myocardiac cells
withelectromicroscopy. We conclude that both Ginsensidein total and Ginsenside Rb have
protective effects onmyocardiac ischemic and reperfusion injuries in openheart surgery, andthe
effect of Ginsenside in total iseven better than that of Ginsenside Rb.
出处
《中华医学杂志》
CAS
CSCD
北大核心
1994年第10期625-628,共4页
National Medical Journal of China
基金
国家自然科学基金