甲襞微循环综合定量法评价前列腺素E_1对老年下肢动脉硬化闭塞症的临床疗效

Evaluation of clinical effects with capillaroscopy in aged patients with low extremity atherosclerosis disease treated by Prostaglandin E_(1)

目的:探讨甲襞微循环综合定量法对于评价前列腺素E1对老年下肢动脉硬化闭塞症患者疗效的临床应用价值。方法:对48例老年下肢动脉硬化闭塞症患者于治疗前及前列腺素E1脂微球载体制剂(Lipo-PGE1)治疗后应用甲襞微循环综合定量法进行微循环观测并作比较。结果:治疗后甲襞微循环总积分值显著降低(P<0.01),各分类积分值均降低(P<0.05),同时甲襞微循环总积分值与踝肱指数存在直线负相关(P<0.01)。结论:甲襞微循环综合定量法对于前列腺素E1治疗老年下肢动脉硬化闭塞症患者的疗效判断具有较高的临床实用价值。

Objective:To investigate the value of nail fold microcirculation in evaluating clinical effects after Lipo-PGE_(1) treatment in aged patients with low extremity atherosclerosis disease (LEASD). Methods:48 male aged LEASD patients were selected from inpatient of the PLA General Hospital and treated by Lipo-PGE_(1). Before and after treatment,the alterations of clinical symptoms, ankle/ brachial index (ABI), nail fold microcirculation of left ring finger were observed and compared. Results:After treatment,the nail fold microcirculation total scores were significantly decreased(P<0.01)and each item^(’)s score was decreased,too(P<0.05).Furthermore, total score was negatively correlative with ABI. Conclusion:The nail fold microcirculation examination has a good practical value in assessing clinical effect in the aged patients with LEASD.