异位性皮炎血清嗜酸细胞阳离子蛋白水平的检测及意义

Detection and biological significance of ECP in atopic dermatitis

目的探讨异位性皮炎(AD)患者的血清嗜酸细胞阳离子蛋白(ECP)、总IgE和外周血嗜酸细胞计数(EOS)之间和疾病严重程度之间的相关性。方法选择门诊就诊的50例AD患者,设30例正常人为对照,同期检测ECP、TIgE和EOS,并对疾病严重程度评分。结果AD患者血清ECP和TIgE水平均明显高于正常对照组(P<0.05)。患者EOS在正常范围之内。ECP与TIgE、EOS之间无相关性,疾病严重程度评分与ECP之间呈正相关(r=0.764,P<0.05),而与TIgE和EOS则无相关性(P>0.05)。结论AD患者血清ECP水平是反映嗜酸粒细胞活化和过敏状态的敏感指标,可更为有效而可靠地监测AD患者病情活动及疗效。

Objective To explore the correlation among serum ECP、Blood eosinophil count(EOS) 、total serum IgE(TIgE) and clinic severity in atopic dermatitis patients.Methods Serum ECP was measured in atopic dermatitis patients ( n =50) and health controls ( n =30), EOS and TIgE were examined at the same time, their interrelation was compared.Results The study showed that the mean levels of serum ECP and serum TIgE in 50 AD were respectively( 20.71 ± 9.96)μg/L and ( 360.42 ± 142.34) mg/L, they were both significantly higher than the levels from healthy controls ( P < 0.05 ), But blood EOS showed no significant change ( P > 0.05 ).The levels of ECP in AD were positive correlation with the clinic severity scores but the TIgE was not. There was no significant correlation among ECP、 TIgE and EOS in AD.Conclusion As a marker for reflecting the allergic status in AD and predicting the inflammatory exacerbation and its severity, ECP is more sensitive than the TIgE and EOS, It is better to reflect the degree of activation of eosinophil.Moreover it might be more useful in allergic diagnoing and monitoring the efficacy of anti inflammatory treatment.