摘要
目的:研究肿瘤坏死因子受体1(tumornercosisfactorreceptors1,TNFR1)在甲状腺癌组织中的表达及其与临床及病理因素的关系。方法:应用免疫组织化学SP法和显微图像分析技术检测41例甲状腺癌中TNFR1的表达,并与9例甲状腺腺瘤及7例腺瘤旁形态学正常的甲状腺组织作对照。结果:①甲状腺癌组织中TNFR1的表达水平显著高于腺瘤组及正常甲状腺组(P<0.001),而在甲状腺腺瘤和正常甲状腺组织中的表达水平无显著性差异(P>0.05)。②在甲状腺癌各临床病理参数中,TNFR1的表达只与病理类型有关,在乳头状癌组中的表达水平高于滤泡状癌组(P<0.05);而与年龄、性别、肿瘤大小、浸润程度及淋巴结转移等因素无关(P>0.05)。结论:TNFR1参与了甲状腺癌的发生发展过程,可以作为甲状腺癌诊断与鉴别诊断的病理学指标之一,但不能作为评估甲状腺癌生物学行为和预后的有关指标。
Objective:To investigate the expression of tumor necrosis factor receptor-1 (TNFR1) in thyroid carcinoma and its relationship with clinicopathological factors.Methods:SP immunohistochemical method was used to determine the expression of TNFR1 in 41 specimens of thyroid cancer tissues,9 thyroid adenomas and 7 normal thyroid tissues adjacent to adenoma.Results:① The level of TNFR1 in thyroid carcinoma was significantly higher than that in thyroid adenomas and normal thyroid tissue (P<0.001),but there was no significant difference between thyroid adenomas and normal thyroid tissue (P>0.05).② In all clinicopathological parameters of thyroid cancer,TNFR1 and pathological types were significantly correlated:TNFR1 expression was up regulated in papillary thyroid cancer (PTC)(P<0.05),but it was not related with other factors such as sex,age,the depth of invasion,lymph node metastasis and the size of tumor (P>0.05).Conclusions:TNFR1 was thought to play a important role in the carcinogenesis of thyroid carcinoma.It would be serve as a pathological index for diagnosis and differential diagnosis of thyroid carcinoma,but it could not be regarded as an useful index for assessing the biological behaviors and prognosis of thyroid carcinoma.
出处
《华北国防医药》
2005年第3期160-161,F003,共3页
Medical Journal of Beijing Military Region
关键词
甲状腺肿瘤
肿瘤坏死因子
免疫组织化学
表达
Thyroid tumors
Tumor necrosis factor,TNF
Immunohistochemistry
Expression