盐酸戊乙奎醚用于重度有机磷中毒的救治

Treatment of severe organophosphorus poisoning with penehyclidine hydrochloride

目的比较盐酸戊乙奎醚与阿托品在救治重度有机磷中毒中的疗效。方法以作者及所在科室既往救治的重度有机磷中毒患者作为对照组,选择新就诊的重度有机磷中毒患者作为治疗组,以盐酸戊乙奎醚替代阿托品作为抗胆碱药物,比较两组的治愈率、病死率、严重并发症的发生率及严重并发症的病死率等。结果对照组总治愈率为80·0%,总病死率为20·0%,中毒治疗时间平均为8·3d,严重并发症的发生率为73·3%,严重并发症的病死率为27·3%。治疗组总治愈率为94·7%,总病死率为5·3%,中毒治疗时间平均为10·2d,严重并发症发生率为47·4%,严重并发症的病死率为11·1%。两组间治愈率、总病死率及严重并发症发生率有显著性差异(P<0·05)。两组间严重并发症的病死率及平均中毒治疗时间上无显著性差异。结论与阿托品相比,盐酸戊乙奎醚能进一步减少严重并发症的发生,降低死亡率,提高治愈率。

Objective To compare the effects of penehyclidine hydrochloride and atropine in the treatment of severe organophosphorus poisoning.Methods The past treated severe organophosphorus poisoning patients were taken as the control. In the treatment group, penehyclidine hydrochloride was used instead of atropine as the anticholinergic agent in the treatment of newly hospitalized severe organophosphorus poisoning, without any change of other treating methods and agents. The cure rates, mortality rates, incidence rates of severe complications and the mortality rates of severe complications of the two groups were calculated and compared respectively. Results In the control group, the cure rates, mortality rates, incidence rates of severe complications and the mortality rates of severe complications were 80.0%, 20.0%, 73.3% and 27.3% respectively. While those were found to be 94.7%,5.3%,47.4% and 11.1% respectively in the treatment group. Conclusion Penehyclidine hydrochloride could be better in increasing the total cure rate, decreasing the total mortality rates and the incidence rates of severe complications than atropine in treating severe organophoshorus poisoning.